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Interactions between the immune, endocrine and nervous systems seldom appear as main issues in the neurosciences and in immunology. So far this was most likely due to the need to focus on the molecular and cellular bases of single neural, endocrine and immune processes. But hormones, neurotransmitters and neuropeptides can also influence more subtle mechanisms underlying immune cell activity. The contents of this volume aim at listing some aspects which show that not only the bases for neuroendocrine control of more refined mechanisms related to the organization and functioning of the immune systems do exist, but also that the immune system can actively communicate with neuroendocrine structures. The evidence is divided into three categories: anatomical, cellular and molecular bases for the exchange of information between immune, endocrine and neural cells; reciprocal effects between immune and neuroendocrine mechanisms; immune-neuroendocrine regulatory circuits. Immunologically triggered neuroendocrine responses can be either beneficial or deleterious for the host. A systematic approach would imply the simultaneous evaluation of neuroendocrine and immune parameters and thus provide the basis for therapeutic interventions based on antagonizing or blocking undesirable effects.
|DATE DE PUBLICATION||2002-Jan-01|
|TAILLE DU FICHIER||7,64 MB|
|NOM DE FICHIER||Neuroendocrine-Immune Interactions.pdf|
Over the past 15 years, the mechanisms by which the brain communicates with the immune system and the immune system with the brain have been elucidated. Increasingly, we are beginning to realize that cytokines within the brain are no scientific oddity, but rather are an important component of normal brain functioning. They are able to alter behaviour, memory, stress responses, brain injury and ...
Interactions between the immune, endocrine and nervous systems seldom appear as main issues in the neurosciences and in immunology. So far this was most likely due to the need to focus on the molecular and cellular bases of single neural, endocrine and im